Wednesday, December 07, 2005

Kucing Botak atau Alopecia

Alopecia ini dapat disebabkan oleh :
1.Neurologic/behavioral - obsessive compulsive disorder,
2.Endocrine-sex hormone alopecia, hyperthyroidism, hyperadrenocorticism, diabetes mellitus,
3.Immunologic-allergic dermatitis, alopecia areata,
4.Parasitic-demodicosis, dermatophytosis,
5.Physiologic-sebaceous adenitis, neoplastic-paraneoplastic dermatitis, squamous cell carcinoma in situ, epidermotropic lymphoma,
6.Idiopathic/inherited-alopecia universalis, hypotrichosis, spontaneous pinnal alopecia, anagen and telogen defluxion
Ini adalah keadaan yang dapat menyebabkan kucing menjadi botak (alopecia) :

Endocrine Alopecia/Sex Hormone
1.Rarely a hormonal abnormality
2.Rare hormonal cases-primarily castrated males; alopecia along the caudal aspect of the hindlimbs, which may extend along the perineum

Obsessive Compulsive Disorder
1.Often misdiagnosed as endocrine
2.The pattern of alopecia is frequently symmetrical with no associated inflammation.

Allergic Dermatitis
1.Varies from mild partial alopecia with little inflammation to severe excoriation and ulceration
2.Distribution-varied; often the head and neck region are most severely affected.
3.Food allergy and inhalant/percutaneous causes

Hyperthyroidism
1.Partial to complete alopecia from self-barbering
2.Varied pattern
3.Middle-aged to old cats
4.Often mistaken for allergic dermatoses, obsessive compulsive disorder, or hormonal

Diabetes Mellitus
1.Partial alopecia with an unkempt hair coat
2.Poor wound healing
3.Increased susceptibility to infections
4.Cutaneous xanthomatosis secondary to hyperlipidemia (nodular to linear, yellow-pink alopecic plaques that tend to ulcerate)

Hyperadrenocorticism
1.Rare; characterized by alopecia and extreme fragility of the skin
2.Truncal alopecia, with or without a rattail and a curling of the pinnal tips
3.Extreme skin fragility noted in approximately 70%
4.Occurs secondary to pituitary or adrenal tumors
5.Iatrogenic form less common in cats than in dogs

Paraneoplastic Alopecia
1.Most cases associated with pancreatic exocrine adenocarcinomas
2.Middle-aged to old cats (9-16 years)
3.Acute onset
4.Progresses rapidly
5.Bilaterally symmetrical, ventrally distributed (also located along the bridge of the nose and periocular)
6.Hair epilates in clumps
7.Rare pruritus
8.Erythema with dry fissuring footpads
9.Glistening appearance to the alopecic skin
10.Skin is thin and hypotonic.
11.Rapid weight loss

Sebaceous Adenitis
1.Slowly progressive partial alopecia associated with scaling along the dorsum of the body and the extremities
2.Sebaceous glands are selectively destroyed by toxic intermediate metabolites or immunologic mechanisms.
3.Possible dramatic pigment accumulation along the eyelid margins
4.Questionable association with systemic disease (e.g., inflammatory bowel disease, lupus-like syndromes, upper respiratory tract infections)

Squamous Cell Carcinoma In Situ
1.Multicentric premalignant dermatosis in old cats
2.Slightly elevated, plaque-like or papillated lesions with scaling and partially alopecic surfaces
3.Often misdiagnosed as seborrhea
4.About 25% may convert to squamous cell carcinoma with in situ lesions along the borders (histologically).

Epidermotrophic Lymphoma
1.Early stages-varying degrees of alopecia associated with scaling and erythema
2.Later stages-plaques and nodules
3.Old cats

Alopecia Areata
1.Rare, complete alopecia in a patchy distribution with no inflammation

Alopecia Universalis (Sphinx Cat)
1.Hereditary
2.Complete absence of primary hairs; decreased secondary hairs
3.Thickened epidermis; normal dermis
4.Sebaceous and apocrine ducts open directly onto the skin surface; oily feel to skin
5.Wrinkled foreheads; gold eyes; no whiskers; downy fur on paws, tip of tail, and scrotum

Feline Hypotrichosis
1.Siamese and Devon Rex cats (autosomal recessive alopecia)
2.Poorly developed primary telogen hair follicles
3.Born with a normal coat; thin and sparse by young adult

Spontaneous Pinnal Alopecia
1.Siamese cats predisposed
2.May represent form of alopecia areata or pattern baldness

Anagen and Telogen Defluxion
1.Acute loss of hair owing to interference with the growth cycle
2.Causes-stress, infection, endocrine disorder, metabolic disorder, fever, surgery, anesthesia, pregnancy, drug therapy

Demodicosis
1.Rare; unlike dogs
2.Partial to complete multifocal alopecia of the eyelids, periocular region, head, and neck
3.Variable pruritus with erythema, scale, and crust, and ceruminous otitis externa
4.Demodex cati (elongated shape) often associated with metabolic disease (e.g., FIV, systemic lupus erythematosus, diabetes mellitus)
5.Unnamed short/blunted Demodex mite is rarely a marker for metabolic disease, this form may be transferable from cat to cat and has been associated with pruritus

Dermatophytosis
1.Numerous clinical manifestations; always associated with alopecia of some degree

Normally para Vets akan melakukan cara-cara ini untuk memperkuatkan diagnosa mereka seperti :
1.Skin biopsy
2.Skin scraping
3.Fungal culture
4.T-shirts to prove self-trauma
5.Food elimination trials
6.Intradermal skin testing


Treatment
1.Therapy is limited for many of these disorders.
2.Behavioral modification or application of a T-shirt may help prevent self-barbering.
3.Removal of an offending dietary item may alleviate the symptoms of food allergy.
3.If the cat is compliant, shampoo and topical therapy may help secondary problems, such as hyperkeratosis in sebaceous adenitis, crusting in demodicosis, secondary bacterial infections, and malodor for greasy conditions.

Pengubatan yang biasanya diberikan oleh para Vets adalah :
1.Obsessive compulsive disorder-amitriptyline (10 mg/cat/day for a 21-day trial)
2.Endocrine alopecia (males)-testosterone supplementation
3.Allergic dermatitis-antihistamines, diet, corticosteroids, hyposensitization vaccine
4.Hyperthyroidism-oral medications such as methimazole (tapazole) or radioactive iodine therapy
5.Diabetes mellitus-regulation of glucose levels (insulin)
6.Hyperadrenocorticism-surgery; no known effective medical therapy
7.Paraneoplastic alopecia-no therapy; often fatal
8.Epidermotropic lymphoma-retinoids (isotretinoin), corticosteroids, interferon
9.Sebaceous adenitis-retinoids, corticosteroids
10.Squamous cell carcinoma in situ-surgical excision, retinoids (topical and oral)
11.Alopecia areata-no therapy; possibly counterirritants
12.Demodicosis-lime sulfur dips at weekly intervals for 4-6 dips; Mitaban and ivermectin have been tried with variable success (dose and frequency of application are questionable)
13.Dermatophytosis-griseofulvin (CAUTION: idiosyncratic toxicity), ketoconazole, itraconazole (pilihan terbaik)


Nah, dari semua ini, apakah Vets tersebut sudah melakukan cara-cara untuk memperkuatkan diagnose mereka ??? Coz penyebab alopecia itu memang banyak dan pengubatan untuk kucing botak itu harus sesuai dengan diagnose dari Vet..
Ini saja yang dapat saya sampaikan...

__________________
Thanx,
@ kcniv a.k.a krayzie kcniv
from kitten websites

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